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The Genetics and Neuroendocrinology of Short Stature International Study

…is a multinational, multicenter, post-marketing research program that is evaluating the long-term safety and effectiveness of Humatrope® (somatropin [rDNA origin] for injection) therapy in pediatric patients.


In addition to tracking the long-term safety and effectiveness of Humatrope in the observational setting GeNeSIS includes four sub-studies:

  • Genetic Analysis Sub-study - investigating the genetic alterations underlying various growth disorders
  • Growth Prediction Sub-study - refining models to accurately predict growth response to GH treatment
  • SHOX Deficiency Sub-study - elucidating the clinical, endocrine, genetic and radiological features of patients with SHOX deficiency (including patients with Turner syndrome)
  • Neoplasia Sub-study - monitoring progression or recurrence of neoplastic disease in children with a history of neoplasia.